Anxiety is a word we hear more of these days, because we now understand the symptoms of anxiety in ways we didn’t in the past. Anxiety is a ‘fight, flight or freeze’ response involving our autonomic nervous system. It is a normal and healthy evolutionary state that helps us to spot danger and survive. But anxiety can often emerge when we aren’t in dangerous situations. It can become a chronic state of being that affects every element of a person’s life.
Often anxiety is grouped with depression (and we know that 1 in 6 people have one of these two conditions). But anxiety is different to depression because it is less about low mood and low motivation, and more about heightened awareness, fear and overthinking.
How does Lion's Mane work? Why could it help anxiety?
The key bioactive compounds in Lion's Mane that are believed to promote neurogenesis are hericenones and erinacines. Hericenones are found in the fruiting body of the mushroom, while erinacines are more concentrated in the mycelium. Both compounds are thought to stimulate the production of NGF, a protein that is crucial for the survival and function of neurons. NGF is particularly important for the growth and maintenance of cholinergic neurons, a type of neuron that uses acetylcholine as its primary neurotransmitter and is essential for cognitive function.
BDNF, like NGF, supports the survival of existing neurons and encourages the formation of new ones, a process known as neurogenesis. BDNF also promotes synaptic plasticity, which is the ability of synapses to strengthen or weaken over time in response to changes in their activity. This is a fundamental mechanism underlying learning and memory. By enhancing the levels of NGF and BDNF, Lion's Mane may potentially contribute to improved cognitive function.
In relation to anxiety, it is hypothesised that Lion's Mane may exert anxiolytic effects through several mechanisms. These include modulation of the hypothalamic-pituitary-adrenal (HPA) axis, a major part of the neuroendocrine system that controls reactions to stress and regulates many body processes. Dysregulation of the HPA axis has been linked to anxiety disorders. Additionally, the enhancement of neurogenesis in the hippocampus, a region of the brain associated with emotion and memory, could play a role in anxiety reduction.
It should be noted though, that while these mechanisms are supported by preclinical studies, more research, particularly in human subjects, is needed to fully understand the extent of Lion's Mane's effects on neurogenesis and anxiety.
Common Symptoms of Anxiety
Anxiety can manifest through a diverse range of symptoms, reflecting the complex interplay of psychological, emotional, and physical factors:
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Emotional and Cognitive Symptoms: These may include irritability and a shorter temper, often resulting from a heightened state of nervousness. Overthinking or paranoia, characterised by excessive worrying and a tendency to anticipate the worst, is also common. People may also experience difficulties in maintaining relationships due to increased sensitivity and emotional reactivity. The mind can also feel unusually busy, with a constant stream of thoughts that can be hard to switch off.
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Physical Symptoms: Insomnia, or trouble sleeping, is a frequent issue among people dealing with anxiety. Profuse sweating, including night sweats, along with appetite changes (either an increase or a decrease), can also occur. Shortness of breath, nausea, and hair loss are other potential physical manifestations. Anxiety can also lead to an increase in restlessness and fidgeting. It's worth noting that anxiety is often associated with certain gastrointestinal problems, including Irritable Bowel Syndrome (IBS).
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Social Symptoms: Anxiety can lead to challenges in social situations, such as trouble socializing or maintaining relationships. Panic attacks, which are intense bursts of fear or discomfort, can be particularly disruptive in social settings.
Treatment For Anxiety
Conventional medications for anxiety can include antidepressants, anti-anxiety medicine and natural remedies like St. John’s Wort. People might also self-medicate using sleeping pills and alcohol. A more natural and gentle (but effective treatment) can be the nootropic Lion’s Mane, and the cannabis compound CBD. But which is better?
Lion’s Mane For Anxiety
Summary
Lion’s Mane is a mushroom that is processed into a supplement to take orally. It has been shown to have positive effects on the mind and body including improved concentration and alertness, as well as reduced anxiety.
A 2010 study showed that just 4 weeks of Lion’s Mane intake could reduce symptoms associated with anxiety including irritation, sensitivity and concentration issues. An animal study also showed that, in mice, anxious behaviours reduced when given Lion’s Mane. A more recent study showed that Lion’s Mane could be used as a promising alternative to antidepressants in the treatment of depression and anxiety.
How To Take Lion’s Mane
To take this supplement, make sure that you select a reputable vendor, such as the one here at JM Wholesale, and follow the instructions on the label. You can safely take up to 3000 mg of Lion’s Mane per day but the dose you choose is specific to your needs. It might be best to start on a low dose, such as 500mg, and work your way up until you feel the effects of the supplement. You can get this supplement as a capsule or take it as a powder in smoothies or food.
Is Lion’s Mane Safe?
Lion’s Mane is safe to use as long as you buy from a supplier that properly tests its products and uses high quality Lion’s Mane. You should not take more than 3000 mg of Lion’s Mane because it has not been properly tested in larger quantities and might cause you some side effects.
What Are The Side Effects?
The reported side effects of Lion’s Mane are:
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Stomach upset
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Nausea
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Hyper-alertness
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Sleep changes
How Long Until I Notice A Difference?
Some people anecdotally report that they feel less anxious after just a couple of days of using Lion’s Mane. Other people say that they feel the effects after 2-4 weeks. Studies have only measured the longer term effects (4 weeks onwards) but you might be lucky enough to feel better before then.
CBD For Anxiety
Summary
CBD is a compound derived from the cannabis plant and has been used for thousands of years to treat physical and mental health concerns. CBD is still being studied and has been subject to some controversy in the past due to its relationship with cannabis / marajuana. But, it’s safe to say that CBD is legal and does not cause a ‘high’.
CBD has been studied for its effects on anxiety symptoms and has shown promising results across multiple studies. Research published in Nature also demonstrates that the linked effects of anxiety (poor sleep, poor appetite, social difficulties) are also positively influenced by taking CBD over a number of weeks.
How To Take CBD
CBD can be taken orally as a capsule, spray or oil. Or, it can be eaten as cakes or cookies, or consumed as a drink. CBD can also be applied topically although this is usually done in the case of treating skin disorders. Lastly, you can vape CBD using a vaping kit.
Any of these methods will effectively treat anxiety.
Is CBD Safe?
CBD is considered safe to use as long as you use a reputable CBD supplier. It should be made clear to you where the CBD is sourced. You should also be given view of any third party lab testing. If you buy CBD through JM Wholesale you can be sure of its authenticity.
What Are The Side Effects?
CBD does not have any significant side effects, but some that have been reported are:
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Dry mouth
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Nausea
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Stomach upset
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Appetite changes
How Long Until I Notice A Difference?
The calming effects of CBD can be felt quickly, or after a few weeks. It really does depend on the dosage and frequency of CBD use. You may need to experiment with the way you consume CBD to determine what works for you. For example, some people find that eating CBD gummies has a rapid effect on their anxiety, whereas others prefer to vape it for an instant hit. Many studies have shown that CBD can reduce anxiety symptoms after 4 weeks of use.
Which is Better? Lion’s Mane or CBD?
CBD and Lion's Mane are both noteworthy contenders in the sphere of natural anxiety remedies, with their potential effects typically peaking after about four weeks of steady use.
CBD, shines in terms of its diverse application methods. You can choose from a spectrum of forms, such as oils, capsules, or even topicals, depending on your convenience and preference. The prevailing characteristic of CBD in anxiety management is its calming effect, likely resulting from its interaction with the body's endocannabinoid system, which has a hand in mood and stress regulation.
Conversely, Lion's Mane, might not boast the variety of consumption methods that CBD does, but it’s usually well-tolerated with minimal side effects. Its distinctive edge lies in its neuroprotective properties, particularly the enhancement of cognitive functions. By stimulating the production of nerve growth factor (NGF), Lion's Mane can foster better concentration and alertness. While it might help quieten the mind, it doesn't impart the same calming effect that CBD does. Instead, it can help manage anxiety by promoting mental clarity and focus.
Some individuals find that a combination of Lion's Mane and CBD offers a more comprehensive approach to anxiety management, leveraging the calming effect of CBD and the cognitive enhancement properties of Lion's Mane. However, it's crucial to keep in mind that individual responses to these substances can vary, and consultation with a healthcare provider is always recommended when considering new potential treatments for anxiety.
Check out our CBD range and Nootropics page for more information on both of these anxiety reducing supplements.
